Medicine Grand Rounds: William H. Kate Hematology Lecture -- David Ginsburg, MD

October 13, 2017 - 8:00am
David Ginsburg, MD

Cargo Receptors in the ER: From Clotting Factor to Cholesterol Regulation

Learning Objectives

  • Understand the Genetic basis and clinical presentation of combined deficiency of Factor V and Factor VIII.
  • Understand the power of modern genetic approaches to uncover the molecular pathogenesis of human disease.
  • Gain an increased appreciation of the potential for basic biological insights from the study of human disease (beside to bench), as well as translational medicine (bench to bedside).
  • Understand the biosynthesis of PCSK9 and its role in the regulation of cholesterol.


  • R35-HL135793, National Institutes of Health D. Ginsburg, P.I. The Molecular Genetics of Hemostasis
  • D. Ginsburg as a Howard Hughes Medical Institute Investigator


Watch from your desk: If you can’t make Medicine Grand Rounds this week, click here to watch a live stream (just enter your Duke Net ID and password).


Weekly Forum