Biochronicity HRV

Research Aims

Experimental Human Rhinovirus (HRV serotype 39) challenge study in healthy volunteers. The purpose of this study is to determine specific biomarker signatures and/or biometric measures predictive of an impending respiratory illness before the onset of symptoms. Participants were equipped with wearable physiologic monitoring devices and inoculated with HRV, and dense, longitudinal sample and data collections were performed spanning pre-inoculation baseline through infection and convalescence. Subjects were enrolled and study was performed in collaboration with the University of Virginia (2010).

Experimental Design

Subjects: 24

Timepoints: 23

Sample types:

  • plasma:2588
  • serum:69
  • PAXgene RNA:76
  • RNA total:428
  • nasal lavage:985
  • nasal swab:180
  • other whole blood:346
  • DNA total:19


Clinical: CRF/clinical, demographics, symptom survey, cognitive survey, wearable device

Molecular: Blood RNAdeq, exome seq, plasma cytokines, plasma metabolites, RIA steroid measures, serology, quantitative viral titer