Research Aims

Molecular and Epidemiological Study of Suspected Infection (MESSI) is an observational multi-visit study enrolling patients in outpatient clinic, emergency department or hospital, as well as patients in the community with suspected symptoms of infection (bacterial, viral, parasitic or tick-borne infection, or with symptoms that mimic infectious illness). The primary objective is to identify biomarkers for early diagnosis, or for prognosis of poor outcome. Since March 2020, MESSI includes subjects with confirmed or suspected SARS-CoV-2 (COVID-19) infection or known exposure. 

Experimental Design

Subjects: 466

Timepoints: Variable up to 10

Sample types:

  • NPOP:5442
  • serum:12050
  • PAXgene RNA:2122
  • plasma:13655
  • PBMC:7159
  • whole blood:51
  • saliva:472
  • urine:29


Clinical: CRF/clinical data, demographics, symptom survey, clinical adjudication

Molecular: Blood RNAseq, PBMC bulk and single-cell RNAseq, PBMC bulk and single-cell ATACseq, whole exome seq, pathogen etiology testing, SARS2 qPCR, SARS2 serology and quant immune assays