2018 Snyderman Scholars
Class of 2019
Mentor: David Hsu, M.D., Ph.D.
Major: Biomedical Engineering and Biology
Project: Predictors of response to anti-FGFR therapy in colorectal cancer
The fibroblast growth factor receptor (FGFR) is a potential therapeutic target for patients with metastatic colorectal cancer (CRC). Sarah aims to identify predictors of response to anti-FGFR therapy in colorectal cancer. Her research will determine the efficacy of targeting the FGFR pathway both in vitro and in vivo in 15 matched patient-derived CRC lines and patient-derived xenografts and identify predictive biomarkers of response to anti-FGFR therapy. Her work may allow for prediction of response to anti-FGFR therapy and development of targeted therapy to treat colorectal cancer.
Class of 2019
Mentor: Charlie Gersbach, Ph.D.
Project: Genome Engineering in Human Cells
Glucocorticoids are used to treat chronic inflammation and autoimmune disorders, but they can cause side effects that reduce the quality of life for patients using them. Vidit aims to better understand the mechanisms of the glucocorticoid transcriptional response by developing CRISPR-based tools. His overall goal is to provide an efficient means to tag proteins to better understand their biological function as well as their role in the glucocorticoid response pathway.