Recent News
Call for Proposals: Holland-Trice Scholars Award for high risk/high impact discovery research in Basic Brain Science and Brain Diseases
Proposals must be received by 5 p.m. EST on Jan. 10, 2022
Watch: Lori Orlando's interview with WRAL on family health history
Orlando recently shared why talking to your loved ones about family health history benefits your future
Duke multi-disciplinary team’s collaboration reveals common and unique viral responses enabling potential for future early testing opportunities
The future of discovery in the world of research goes beyond the walls of core teams. Collaboration across institutions, countries, and around the world will answer the biggest questions in years to come.
Call for papers: Dissecting the role of immune responses in complex brain disorders: translational and clinical insights
Submission deadline extended to January 5, 2022
Tsalik, McClain, Ginsburg, Woods publish, “Comparing the Diagnostic Accuracy of Clinician Judgement to a Novel Host Response Diagnostic for Acute Respiratory Illness”
Host gene expression-based tests are a promising strategy to discriminate bacterial and viral etiologies, but their potential clinical utility has not yet been evaluated.
New CDC Partnerships to Advance the Development and Validation of Next Generation Sequencing Tests: A Publicly Available List of Expert Curated Variants
Over the last decade, genetic testing has evolved from examining a few well-defined variants in one or a few genes to the capability to examine much of the human genome using next generation sequencing (NGS).
Events
Duke University Postdoc Association: Research Soapbox
December 2, 2021 - 12:00pm
Medicine Grand Rounds: The Challenge with Studying Cardiovascular Disease
December 3, 2021 - 12:00pm
Computational Biology & Bioinformatics Seminar Series
December 6, 2021 - 12:00pm
Artificial Intelligence: Capabilities, Liabilities, and Responsibilities
December 7, 2021 - 3:00pm
Genomic Seminar Series: Charis Eng, MD, PhD, FACP
December 7, 2021 - 4:00pm
Genomic & Precision Medicine Forum Series: Elizabeth Hauser, PhD
December 9, 2021 - 12:00pm
New Funding
Micah McClain has received an award from Biomeme, Inc. for a project entitled "Biomeme Franklin ISP SARS-CoV-2 + Influenza Multiplexed RT-PCR Test Point of Care Study including Saletto Oral Fluid Collection."
Lori Orlando, MD, MHS, has received an award (1R01-HG011794-01) from the National Institutes of Health for a project entitled "Deploying a genomic-medicine risk assessment model for diverse primary care populations and settings."
Geoffrey Ginsburg, MD, PhD has received an award (5U01-HG010225-04S1) from the National Institutes of Health for a project entitled "The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination."
Ephraim Tsalik, MD, PhD, has received an award (W81XWH2110741-PR201197) from the Department of Defense for a project entitled "Rapid, point-of-care, host gene expression test for presymptomatic viral infection and to distinguish bacterial from viral illness."
Christopher Woods received a sub-award (W911QY-19-9-0006) through the Henry M. Jackson Foundation for a project entitled "Prophylaxis and Treatment of COVID19 Adaptive Platform Trial (PROTECT-APT)." (June 2021, Sponsored Research)
Featured Publications
A Gene Expression Signature Reflective of Exposure to Antiplatelet Therapy is Associated with Bleeding
Deepak Voora, Rachel Myers, Ilya Zhannikov, Geoffrey Ginsburg find biosignatures composed of gene expression data hold promise for personalized antiplatelet therapy in conjunction with current guidelines and risk scores. (AHA Journals/Circulation)
Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases
Jeanette McCarthy and co-authors discuss diagnostic performance of Fabric GEM, a new, AI-based, clinical decision support tool for expediting genome interpretation. (Genome Medicine, part of Springer Nature)
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset
Micah McClain, Christopher Woods, Ephraim Tsalik, Ricardo Henao, Geoffrey Ginsburg and team investigate the power of wearables to detect viral illness. (JAMA Network Open)
Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients
Ryanne Wu, Lori Orlando, and Geoffrey Ginsburg explore perceptions of the value of knowing one’s family health history (FHH)-based risk and potential implementation of a FHH tool (Journal of Personalized Medicine)
Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD
Douglas E. Williamson and co-authors investigate evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD. (ScienceDirect - Neurobiology of Stress)
Use of Machine Learning–Based Software for the Screening of Thyroid Cytopathology Whole Slide Images
Ricardo Henao and co-authors evaluate the ability of the machine learning algorithm and screening software to identify and screen for a subset of informative ROIs on a thyroid FNA WSI (Archives of Pathology & Laboratory Medicine)
Core Resources
Diagnostics Development Laboratory
The laboratory brings together expertise in molecular microbiology with genome sciences to develop next-generation diagnostic tests.
BioBank
We support biobanking activities including IRB, sample collection, processing, storage, bar-coded chain of custody and e-inventory management.
Data Science and Analytics
We provide support for data management and integration, informatics, and statistical analyses on complex ‘-omics’ and clinical datasets.