About the Center

The path from gene discovery to effective clinical applications is complex and challenging. Enhanced efficiencies in health care health delivery and quantifiable improvement in human health are major goals of genomic (and its derivative ‘omics) research. Discovery, development and application of genome-based diagnostic and prognostic tests require both an interdisciplinary science strategy as well as a pragmatic implementation strategy for successful translation. The Duke Center for Applied Genomics & Precision Medicine was created to focus on developing these strategies and capabilities to enhance our ability to diagnose and predict patient outcomes across the continuum from health to disease.

The major missions of the Center, carried out by its Programs in Applied Genomics and Programs in Precision Medicine are discovery research, implementation science, and outcomes and education. 

The Center aspires to be an intellectual home for genome-inspired biomarker discovery and development and the analytic and translational approaches to diagnostics and insights into disease biology. It is also a home for the rapidly evolving field of precision medicine - an evidence-based approach to the care of people and patients that uses innovative tools and data science to customize disease prevention, detection and treatment and improve the effectiveness and quality of care.

The Center is highly interdisciplinary with ties to the health system and to university-wide faculty and students. As a hub and catalyst, the Center maintains strong, clear connections to other translational units at Duke, for example the Clinical and Translational Science Award programs, to help investigators unleash their full translational potential to advance this important area of science.

The Center currently has three strategic areas of focus:

  • Innovative discovery and translational research to discover novel genome-inspired technologies and molecular profiles (biomarkers) for risk prediction, diagnosis, prognosis, and prediction using novel quantitative models and methods to evaluate their clinical validity and utility and to assess how these advances add to currently available clinical models. 
  • Implementation science strategies and programs for genome-inspired technologies and molecular profiles the dissemination of best practices for the implementation of these technologies into the health care environment - including data sharing, crowd sourcing, mobile/ehealth and patient and provider engagement in outcomes research.
  • Education programs for trainees, providers, and patients on how best to apply genomic knowledge to the day-to-day care of Duke patients and for similar programs locally, nationally and internationally.

It is my vision and hope that the Duke Center for Applied Genomics & Precision Medicine will allow the Duke Medicine community to be a global leader in developing innovative precision medicine tools and enabling their impact on helping people optimize their health and patients and providers to mange their disease.

Geoffrey S Ginsburg, MD, PhD, Director